The primary mission of the vascular surgery basic science lab is to develop an advance generation of cardiovascular materials, devices, and pharmacotherapeutics based upon the principles of biomimetics, molecular engineering, and nanofabrication technologies. Over the past 11 years, the program has received over 16.7 million dollars of funding from the NIH. Other sponsors include the NSF and the JDRF. The program is integrated with The Wallace Coulter Department of Biomedical Engineering at Georgia Tech and Emory and the Department of Chemistry at Emory. For more details, visit the lab's official website and see the listings below of ongoing investigations and completed investigations.



ONGOING INVESTIGATIONS

NIH/NHLBI, A Bioinspired Small Diameter Vascular Conduit, R01 HL083867, 7/1/06–7/30/11

NIH/NHLBI, Protein Fibers as Design Elements for an Arterial Conduit, RO1HL71336, 8/1/02–7/31/07

NIH/NHLBI, Antithrombogenic Membrane-Mimetic Assemblies, RO1HL56819, 7/1/06–12/30/11

NIH/NHLBI, Autogeneration of an Artery: A Biomimetic Strategy, RO1HL60464, 7/1/04–6/30/08

NIH/NIDDK, A Biomimetic Barrier for Islet Immunoisolation, RO1DK069275, 7/1/04–6/30/09

NIH/NHLBI, Syndecan Shedding in Vascular Lesion Formation, RO1HL60963, 6/30/03–2/28/07

NSF, ERC for the Engineering of Living Tissues, EEC-9731643 E-15-AO1-G1, 09/01/98–08/31/08

NSF, Bio-inspired Materials for Heart Valve Design, EEC-9731643 E-15-AO1-G1, 09/01/98–08/31/07

NSF, Protein-Based Colloidal Nanoparticles for Sustained Local Release of Anti-Inflammatory Agents, EEC-9731643 E-15-AO1-G1, 01/01/2002–08/31/07

JDRF, An Anti-inflammatory Immunoisolation Barrier for Islet Transplantation, 11/1/05–10/31/10

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Molecular Design of Biomaterials for Tissue Regeneration, Emory/Georgia Tech Biomedical Technology Research Center, 7/1/94–6/30/95

The Biology of Thrombin Receptor Regulation in Cell-Mediated Graft Failure, American Heart Association, National Center, 7/1/94–6/30/99

Phospholipid Biomaterials for Engineered Tissue Regeneration, American College of Surgeons, 7/1/94–6/30/96

Phospholipid Biomaterials for Engineered Tissue Regeneration, Emory University Research Committee, 9/1/94–8/31/95

Biomolecular Materials for Engineered Tissue Regeneration, Whitaker Foundation, 12/1/94–11/30/97

An Endovascular Polymeric Prosthesis for Minimally Invasive Aortic Surgery, Emory/Georgia Tech Biomedical Technology Research Center, 7/1/95–6/30/96

Self-Assembling Polyamide Monolayers on Gold: Stability and Phase Behavior of Multicomponent Systems, Polymer Engineering Research Center, Georgia Institute of Technology, 1/1/96–6/30/96

Chemical and Biological Modification of Polymer Fiber, Hoechst-Coelonese, Inc., 1/1/96–12/31/96

Membrane-Mimetic Assemblies for Endothelial Migration, National Institutes of Health (R29HL56819), 7/1/96–12/30/00

Micropatterned Biocompatible Materials: Manipulating Homotypic and Heterotypic Endothelial/Mesenchymal Cell Interactions, Emory/Georgia Tech Biomedical Technology Research Center, 7/1/96–6/30/97

A Biomimetic Barrier for Islet Immunoisolation, Juvenile Diabetes Foundation International, 9/1/98–8/31/00

Quantitative 3-D Analysis of Cell Motility, Emory/Georgia Tech Biomedical Technology Research Center, 7/1/98–6/30/99

Heparan Sulfate-Mimetic Glycopolymers For Accelerated Wound Healing, National Institutes of Health (P30AR42687), 7/1/99–6/30/00

Self-Organizing Biocomposite Materials, ONR, 7/1/95–6/30/02

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