Research at Grady Memorial Hospital
Grady Memorial Hospital in metro Atlanta — an internationally recognized teaching hospital with a historic commitment to serving the health needs of the most vulnerable — is among the largest public hospitals in the Southeast. Physicians of the Emory University School of Medicine provide about 80% of the care at Grady, with the other 20% is provided by Morehouse School of Medicine and Grady-employed physicians.
Faculty of the Emory Department of Surgery are members of the physician staff of Grady's Level I trauma center, surgical critical care service, burn center, and the hospital's breast cancer, cardiothoracic surgery, oral and maxillofacial surgery, plastic and reconstructive surgery, and vascular surgery programs.
The size of Grady's service area, the hospital's large and diverse in- and out-patient volume, and the multiplicity of conditions the hospital treats affords vast opportunities for Emory Surgery physician-researchers to conduct significant investigative studies and clinical trials.
Dr. Gabram is surgeon-in-chief for the Emory Department of Surgery at Grady Memorial Hospital; director of the Avon Comprehensive Breast Center at Grady, a model program for providing breast health care services to underserved communities; and deputy director of the Georgia Cancer Center for Excellence at Grady, which is dedicated to expanding cancer care for medically underserved men and women in metropolitan Atlanta.
Dr. Gabram serves as principal investigator on Winship Cancer Institute of Emory University's AVON Foundation grant. In this role she focuses on decreasing disparities in breast cancer care through a community education outreach program and providing access to high quality care for breast cancer patients in the Grady Health System. Dr. Gabram is also the principal investigator on a statewide genomics grant that involves identifying women at high risk for breast and ovarian cancer with referral to genetic counseling and testing when appropriate.
Dr. Subhedar works with Dr. Gabram at the Avon Comprehensive Breast Center, providing comprehensive care for patients with breast disease. Her research interests include investigating healthcare disparities in breast cancer treatment, improving health literacy and access to treatment, and developing treatment methods tailored to breast cancer molecular subtypes.
She is the principal investigator on a V Foundation Mission Grant that is working to identify the specific barriers and motivators that affect minority involvement in breast cancer clinical trials. She is also the Emory PI at Grady for the Alliance 11202 multi-institutional study sponsored by the Alliance for Clinical Trials in Oncology. This trial is comparing the benefit of axillary dissection versus axillary radiation in node positive patients undergoing neoadjuvant chemotherapy.
During her postgraduate training years, Dr. Williams won three best oral presentation awards at annual meetings of the Southern Regional Burn Conference. As a surgical critical care fellow at Grady from 2015-2016, she initiated a clinical trial that evaluated non-invasive cardiac output monitoring in burn patients.
As an Emory Surgery faculty member and a burn surgeon and critical care intensivist at Grady, Dr. Williams' current research includes studies of the use of amniotic membrane on burn donor sites, the role of palliative care in the Grady Burn Center, epoprostenol versus inhaled nitric oxide for inhalation injury, the use of PROKERA rings in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), and the application of MEDIHONEY for partial thickness facial burns.
Dr. Bouloux is the chief of the oral surgery service at Grady. He has conducted several studies of temporomandibular joint dysfunction (TMJ), including a five-year, Oral and Maxillofacial Surgery Foundation-funded clinical study that compared the injection of hyaluronic acid, corticosteroid, and placebo during arthrocentesis for TMJ. He has also evaluated reconstruction plates used in the management of jaw fractures and mandibular resection, and investigated the metal hypersensitivity that can develop following total joint replacement.
Dr. Shapiro is the trauma medical director of the Grady Health System. His research is focused on identifying the best methods of training for both surgical residents and elite combat medics, with a concentration on live tissue training vs. simulation. In addition, he is investigating surgical infection, ventilator-associated pneumonia, and outcomes in the traumatically injured and those undergoing emergency surgery.
Dr. Dente's current research is focused on the creation and use of biomarker and clinical data warehouse-based decision support tools. He is the principal investigator of the Emory site of a Department of Defense (DoD)-funded pilot wound closure study that is working to develop a predictive system for wound closure based on the identification of chemical and molecular biomarkers in informed consent-derived tissue and fluid samples that appear to forecast successful closure. He is also the lead site investigator at Grady's trauma center for the multi-center Surgical Critical Care Initiative (SC2i), also sponsored by the DoD. SC2i is translating decision-making tools developed by the DoD for the battlefield to civilian critical care.
Dr. Gelbard is a member of the SC2i site investigator team at Grady, and she and her colleague Dr. Bryan Morse (see below) are collecting blood and tissue samples for mechanistic assays, physiological data, and radiology and surgical procedures and outcomes data from trauma patients that have given informed consent. Dr. Gelbard is also participating in a national study that is investigating the effect of early cooling in acute subdural hematoma patients.
Dr. Morse is the director of trauma research at Grady. As mentioned above, he joins Dr. Gelbard as a site investigator for the SC2i study. He is also evaluating the efficacy of a smartphone application for the prediction of massive transfusion protocol, and is the primary site investigator for a multicenter, DoD-funded prospective observational study of the use of the Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) device in trauma at Grady. His additional research pursuits include clinical outcomes related to surgery for coagulopathy in critically injured trauma patients, penetrating cardiac injuries, quality improvement in acute care surgery and trauma, and clinical outcomes in geriatric patients after emergent surgery and trauma.
Dr. Rajani is the chief of the vascular and endovascular surgery service at Grady. He has served as the principal investigator for several trauma-specific clinical trials, and is particularly interested in refining thoracic stent graft technology for treating blunt aortic injury. He is currently the national PI of a prospective, multicenter, non-blinded, non-randomized study of the RelayPro Thoracic Stent-Graft in subjects with traumatic injury of the descending thoracic aorta.
Dr. Benarroch-Gampel is the Emory lead for the Grady site of the RelayPro Thoracic Stent-Graft study that Dr. Rajani is directing. His additional research interests include development of large databases to evaluate patterns in the use of diagnostic tests, examination of clinical outcomes after vascular surgery interventions, and the assessment of factors that affect quality of care.
Dr. Teodorescu's research focuses on lower extremity peripheral artery disease, particularly the evaluation of stem-cell therapy for non-reconstructive disease; ultrasound; and all aspects of hemodialysis access. The latter interest has led to her being named to the divisional and medical review boards of the Network of the South Atlantic of the IPRO End Stage Renal Disease (ESRD) Network, for which she evaluates public health policy and outcomes for this very sick patient population.