– Assistant Professor of Surgery, Cardiothoracic Research Laboratory, Department of Surgery, Emory University School of Medicine
– Member, Molecular and Systems Pharmacology Graduate Program, Emory University School of Medicine
Dr. Calvert's primary research focuses on the pathophysiology of cardiovascular disease, with recent studies investigating the ability of hydrogen sulfide to activate cytoprotective-signaling cascades in the settings of acute myocardial ischemia and heart failure. This research has demonstrated that a concentrated administration of hydrogen sulfide either prior to ischemia or at reperfusion significantly ameliorates in vivo myocardial ischemia-reperfusion injury in mice, with a clear reduction in myocardial infarction, oxidative stress, apoptosis, and contractile dysfunction. These studies have also found that hydrogen sulfide significantly attenuates the progression of ischemic-induced heart failure and improves survival following myocardial infarction. Dr. Calvert's lab has identified the transcription factor Nrf2 as a major cellular target for hydrogen sulfide and a possible regulator of the cardioprotective effects it induces, and is examining how hydrogen sulfide activates Nrf2 in models of heart failure and diabetes.
Other projects are evaluating the cardioprotective signaling mechanisms of voluntary exercise training, particularly the role of nitric oxide and beta-adrenergic signaling.
Grant awards from the National Institutes of Health and the American Diabetes Association have supported Dr. Calvert's research since he established his independent laboratory in 2008, and his findings have been published in such high impact journals as Circulation, Circulation Research, and Atherosclerosis, Thrombosis, and Vascular Biology.
View Dr. Calvert's publications in PubMed.
PhD in Physiology, Loma Linda University, received 2005
Postdoctoral Fellowship in Molecular Cardiology, Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, 2006-2008
American Heart Association (AHA), Fellow
AHA Council on Basic Cardiovascular Sciences: Chairman, Membership/Communications Committee; Member-at-Large, Leadership Committee; International Mentoring Chair
American Physiological Society
American Diabetes Association
International Society of Heart Research
Associate Editor, Medical Gas Research
Editorial Board, Frontiers in Striated Muscle Physiology
Academic Editor, PLOS ONE
Best Poster Award-Core Five, AHA Scientific Sessions, 2011
Best of AHA Specialty Conferences Poster Award, AHA Scientific Session, 2010
Lars-Erik Gelin Conference Travel Award, 25th Conference of the European Society for Microcirculation Integrating Vascular Biology & Medicine, Basic and Clinical Science, Budapest, Hungary, 2008
Mechanisms of cardioprotection in the setting of acute myocardial ischemia-reperfusion injury and heart failure
Cardioprotective signaling mechanisms of hydrogen sulfide in heart failure and the diabetic heart
Cardioprotective signaling mechanisms of exercise