Faculty Profile

Chrystal M. Paulos, PhD

Chrystal M. Paulos, PhD

Primary Appointments:

Associate Professor, Division of Surgical Oncology, Department of Surgery, Emory University School of Medicine

Director, Translational Research for Cutaneous Malignancies, Winship Cancer Institute of Emory University

Secondary Appointment:

Associate Professor, Department of Microbiology and Immunology, Emory University School of Medicine



Year Joined Emory as a Faculty Member



Prior to joining Emory, Dr. Paulos was the Cecilia and Vincent Peng Endowed Chair in Melanoma at the Medical University of South Carolina. She also served as co-leader of the Cancer Immunology Research Program and director of the Adoptive Cancer Immunotherapy Program at Hollings Cancer Center in Charleston, SC.

Dr. Paulos received her PhD in Biochemistry from Purdue University in West Lafayette, IN. She completed her post-doctoral training in genetherapy at the University of Pennsylvania in Philadelphia, and in tumor immunology at the National Institutes of Health in Bethesda, MD.

The objective of Dr. Paulos' research is to develop novel T cell-based therapies for patients with melanoma. Her laboratory seeks to identify mechanisms underlying protective immunity in solid tumors, with an emphasis on adoptive T cell transfer (ACT) therapy. By combining basic and translational understanding of human T cells in clinical studies with mechanistic studies in relevant mouse models and in investigator-initiated clinical trials in patients, her research team has contributed significant insight into the various roles of how to mount T cell memory responses to tumors.



  • Winship Cancer Institute


  • BS with Honors, Truman State University, Kirksville, MO, Class of 1997

  • PhD in Biochemistry, Purdue University, West Lafayette, IN, 1998-2004

  • National Cancer Institute Postdoctoral Research Fellow in Tumor Immunology, Surgery Branch, National Institutes of Health, Bethesda, MD, 2004-2007

  • University of Pennsylvania Postdoctoral Research Fellow in Genetherapy, Translational Research Program, Abramson Cancer Center, Philadelphia, PA, 2007-2011

Current Organizational Memberships

  • Society for Immunotherapy of Cancer

  • International Society for Biological Therapy of Cancer

  • American Association of Immunologists

  • Alliance for Cancer Gene Therapy

  • Standing Member, Cancer Immunopathology and Immunotherapy Study Section, NIH

Research Interests

  • Identification of mechanisms underlying protective immunity in solid tumors

  • Adoptive T cell transfer (ACT) therapy